RHEUMATOID ARTHRITIS

rheumatoid joint inflammation is a ceaseless foundational auto resistant issue causing a numerous poly joint pain 

The study of disease transmission RA influences 0.5-1% of the populace worldwide with top commonness between the ages of 30-50 years Etiology AND PATHOGENESIS 

Sex: Women before the menopause are influenced multiple times all the more regularly then men with an equivalent sex occurrence, there in the wake of recommending an aetiological job of sex harmones 

FAMILIAL: There is expanded rate in those with a family ancestry of RA 

Hereditary FACTORS :Human leucocyte antigen(HLA)- DR4 AND HLA-DRB1 are susceptable to RA and related with advancement of increasingly serious erosive malady 

PATHOLOGY 

RA is portrayed by synovitis with thickening of the synovial covering and invasion by provocative cells age of new synovial veins is instigated by angiogenic cytokines initiated endothelial cells produce grip particles, vascular cell attachment atom 1(VCAM-1) Which speed up extravasation of leucocytes into the synovium The synovium multiplies and becomes out over the outside of ligament, creating a tumor like mass called PANNUS Pannus destroyes the articular ligament and subchondral bone, delivering hard disintegrations 

CLINICAL FEATURES 

• beginning of torment
•  early daytime stiffness(lasting over 30 minutes)
•  expanding in the little joints of hand and feet 
• as the sickness advances there is debilitating of joint containers 
• joint shakiness 
• sub luxation 
• deformityRHEUMATOID ARTHRITIS 

rheumatoid joint inflammation is an interminable foundational auto insusceptible issue causing a numerous poly joint inflammation The study of disease transmission RA influences 0.5-1% of the populace worldwide with top commonness between the ages of 30-50 years Etiology AND PATHOGENESIS 

Sexual orientation: Women before the menopause are influenced multiple times all the more frequently then men with an equivalent sex rate, there in the wake of proposing an aetiological job of sex harmones 

FAMILIAL: There is expanded rate in those with a family ancestry of RA 

Hereditary FACTORS :Human leucocyte antigen(HLA)- DR4 AND HLA-DRB1 are susceptable to RA and related with improvement of progressively extreme erosive infection 

PATHOLOGY 

RA is described by synovitis with thickening of the synovial coating and penetration by fiery cells age of new synovial veins is actuated by angiogenic cytokines initiated endothelial cells produce bond particles, vascular cell attachment atom 1(VCAM-1) Which speed up extravasation of leucocytes into the synovium The synovium multiplies and becomes out over the outside of ligament, creating a tumor like mass called PANNUS Pannus destroyes the articular ligament and subchondral bone, delivering hard disintegrations 

CLINICAL FEATURES 

•  beginning of torment 
•  early daytime stiffness(lasting over 30 minutes) 
• expanding in the little joints of hand and feet 
• as the malady advances there is debilitating of joint containers 
• joint unsteadiness 
• sub luxation 
• deformity 

Foundational: fever,fatigue and weight reduction 

NON-ARTICULAR MANIFESTATIONS OF RA 

EYES: Scleritis, scleromalacia perforans(perforation of the eye) 

NEUROLOGICAL:Carpel burrow disorder, atlanto pivotal subluxation and line pressure 

Hematological : Lymphadenopathy, feltys syndrome(rheumatoid joint pain, splenomegaly and neutropenia), anaemia(chronic malady, NSAID-induced,gastrointestinal blood misfortune, haemolysis and hypersplenism) thrombocytosis 

Pneumonic: Pleural emission, lung fibrosis, rheumatoid nodules,rheumatoid pneumoconiosis 

HEART AND PERIPHERAL VESSELS:Pericarditis,pericardial radiation and raynauds malady 

VASCULITIS:Leg ulcers,nail overlay infracts and gangrene of fingers and toes 

KIDNEYS: Amyloidosis acuses the nephrotic disorder and renal disappointment Confusions OF RHEUMATOID ARTHRITIS 

• Ruptured ligament 
•  Ruptured joints (dough punchers growths) 
• Joint contamination 
• Spinal string compression(atlanto hub or upper cervical spine) 
•  Amyloidosis(rare) RHEUMATOID ARTHRITIS 

rheumatoid joint inflammation is an interminable foundational auto insusceptible issue causing a numerous poly joint inflammation 

The study of disease transmission RA influences 0.5-1% of the populace worldwide with top commonness between the ages of 30-50 years 

Etiology AND PATHOGENESIS 

Sexual orientation: Women before the menopause are influenced multiple times all the more frequently then men with an equivalent sex rate, there in the wake of proposing an aetiological job of sex harmones 

FAMILIAL: There is expanded rate in those with a family ancestry of RA 

Hereditary FACTORS :Human leucocyte antigen(HLA)- DR4 AND HLA-DRB1 are susceptable to RA and related with improvement of progressively extreme erosive infection 

PATHOLOGY 

RA is described by synovitis with thickening of the synovial coating and penetration by fiery cells age of new synovial veins is actuated by angiogenic cytokines initiated endothelial cells produce bond particles, vascular cell attachment atom 1(VCAM-1) Which speed up extravasation of leucocytes into the synovium The synovium multiplies and becomes out over the outside of ligament, creating a tumor like mass called PANNUS Pannus destroyes the articular ligament and subchondral bone, delivering hard disintegrations 

CLINICAL FEATURES 

•  beginning of torment 
• early daytime stiffness(lasting over 30 minutes) 
• expanding in the little joints of hand and feet
• as the malady advances there is debilitating of joint containers
• joint unsteadiness
• sub luxation 
• deformity 

Foundational: fever,fatigue and weight reduction 

NON-ARTICULAR MANIFESTATIONS OF RA 

EYES: Scleritis, scleromalacia perforans(perforation of the eye) 

NEUROLOGICAL:Carpel burrow disorder, atlanto pivotal subluxation and line pressure 

Hematological : Lymphadenopathy, feltys syndrome(rheumatoid joint pain, splenomegaly and neutropenia), anaemia(chronic malady, NSAID-induced,gastrointestinal blood misfortune, haemolysis and hypersplenism) thrombocytosis 

Pneumonic: Pleural emission, lung fibrosis, rheumatoid nodules,rheumatoid pneumoconiosis 

HEART AND PERIPHERAL VESSELS:Pericarditis,pericardial radiation and raynauds malady 

VASCULITIS:Leg ulcers,nail overlay infracts and gangrene of fingers and toes 

KIDNEYS: Amyloidosis acuses the nephrotic disorder and renal disappointment 

Confusions OF RHEUMATOID ARTHRITIS 

• Ruptured ligament 
• Ruptured joints (dough punchers growths) 
• Joint contamination 
• Spinal string compression(atlanto hub or upper cervical spine) 
•  Amyloidosis(rare)s