RHEUMATOID ARTHRITIS
rheumatoid joint inflammation is a ceaseless foundational auto resistant issue causing a numerous poly joint pain
The study of disease transmission RA influences 0.5-1% of the populace worldwide with top commonness between the ages of 30-50 years Etiology AND PATHOGENESIS
Sex: Women before the menopause are influenced multiple times all the more regularly then men with an equivalent sex occurrence, there in the wake of recommending an aetiological job of sex harmones
FAMILIAL: There is expanded rate in those with a family ancestry of RA
Hereditary FACTORS :Human leucocyte antigen(HLA)- DR4 AND HLA-DRB1 are susceptable to RA and related with advancement of increasingly serious erosive malady
PATHOLOGY
RA is portrayed by synovitis with thickening of the synovial covering and invasion by provocative cells age of new synovial veins is instigated by angiogenic cytokines initiated endothelial cells produce grip particles, vascular cell attachment atom 1(VCAM-1) Which speed up extravasation of leucocytes into the synovium The synovium multiplies and becomes out over the outside of ligament, creating a tumor like mass called PANNUS Pannus destroyes the articular ligament and subchondral bone, delivering hard disintegrations
CLINICAL FEATURES
- beginning of torment
- early daytime stiffness(lasting over 30 minutes)
- expanding in the little joints of hand and feet
- as the sickness advances there is debilitating of joint containers
- joint shakiness
- sub luxation
- deformityRHEUMATOID ARTHRITIS
rheumatoid joint inflammation is an interminable foundational auto insusceptible issue causing a numerous poly joint inflammation The study of disease transmission RA influences 0.5-1% of the populace worldwide with top commonness between the ages of 30-50 years Etiology AND PATHOGENESIS
Sexual orientation: Women before the menopause are influenced multiple times all the more frequently then men with an equivalent sex rate, there in the wake of proposing an aetiological job of sex harmones
FAMILIAL: There is expanded rate in those with a family ancestry of RA
Hereditary FACTORS :Human leucocyte antigen(HLA)- DR4 AND HLA-DRB1 are susceptable to RA and related with improvement of progressively extreme erosive infection
PATHOLOGY
RA is described by synovitis with thickening of the synovial coating and penetration by fiery cells age of new synovial veins is actuated by angiogenic cytokines initiated endothelial cells produce bond particles, vascular cell attachment atom 1(VCAM-1) Which speed up extravasation of leucocytes into the synovium The synovium multiplies and becomes out over the outside of ligament, creating a tumor like mass called PANNUS Pannus destroyes the articular ligament and subchondral bone, delivering hard disintegrations
CLINICAL FEATURES
- beginning of torment
- early daytime stiffness(lasting over 30 minutes)
- expanding in the little joints of hand and feet
- as the malady advances there is debilitating of joint containers
- joint unsteadiness
- sub luxation
- deformity
Foundational: fever,fatigue and weight reduction
NON-ARTICULAR MANIFESTATIONS OF RA
EYES: Scleritis, scleromalacia perforans(perforation of the eye)
NEUROLOGICAL:Carpel burrow disorder, atlanto pivotal subluxation and line pressure
Hematological : Lymphadenopathy, feltys syndrome(rheumatoid joint pain, splenomegaly and neutropenia), anaemia(chronic malady, NSAID-induced,gastrointestinal blood misfortune, haemolysis and hypersplenism) thrombocytosis
Pneumonic: Pleural emission, lung fibrosis, rheumatoid nodules,rheumatoid pneumoconiosis
HEART AND PERIPHERAL VESSELS:Pericarditis,pericardial radiation and raynauds malady
VASCULITIS:Leg ulcers,nail overlay infracts and gangrene of fingers and toes
KIDNEYS: Amyloidosis acuses the nephrotic disorder and renal disappointment Confusions OF RHEUMATOID ARTHRITIS
- Ruptured ligament
- Ruptured joints (dough punchers growths)
- Joint contamination
- Spinal string compression(atlanto hub or upper cervical spine)
- Amyloidosis(rare) RHEUMATOID ARTHRITIS
rheumatoid joint inflammation is an interminable foundational auto insusceptible issue causing a numerous poly joint inflammation
The study of disease transmission RA influences 0.5-1% of the populace worldwide with top commonness between the ages of 30-50 years
Etiology AND PATHOGENESIS
Sexual orientation: Women before the menopause are influenced multiple times all the more frequently then men with an equivalent sex rate, there in the wake of proposing an aetiological job of sex harmones
FAMILIAL: There is expanded rate in those with a family ancestry of RA
Hereditary FACTORS :Human leucocyte antigen(HLA)- DR4 AND HLA-DRB1 are susceptable to RA and related with improvement of progressively extreme erosive infection
PATHOLOGY
RA is described by synovitis with thickening of the synovial coating and penetration by fiery cells age of new synovial veins is actuated by angiogenic cytokines initiated endothelial cells produce bond particles, vascular cell attachment atom 1(VCAM-1) Which speed up extravasation of leucocytes into the synovium The synovium multiplies and becomes out over the outside of ligament, creating a tumor like mass called PANNUS Pannus destroyes the articular ligament and subchondral bone, delivering hard disintegrations
CLINICAL FEATURES
- beginning of torment
- early daytime stiffness(lasting over 30 minutes)
- expanding in the little joints of hand and feet
- as the malady advances there is debilitating of joint containers
- joint unsteadiness
- sub luxation
- deformity
Foundational: fever,fatigue and weight reduction
NON-ARTICULAR MANIFESTATIONS OF RA
EYES: Scleritis, scleromalacia perforans(perforation of the eye)
NEUROLOGICAL:Carpel burrow disorder, atlanto pivotal subluxation and line pressure
Hematological : Lymphadenopathy, feltys syndrome(rheumatoid joint pain, splenomegaly and neutropenia), anaemia(chronic malady, NSAID-induced,gastrointestinal blood misfortune, haemolysis and hypersplenism) thrombocytosis
Pneumonic: Pleural emission, lung fibrosis, rheumatoid nodules,rheumatoid pneumoconiosis
HEART AND PERIPHERAL VESSELS:Pericarditis,pericardial radiation and raynauds malady
VASCULITIS:Leg ulcers,nail overlay infracts and gangrene of fingers and toes
KIDNEYS: Amyloidosis acuses the nephrotic disorder and renal disappointment
Confusions OF RHEUMATOID ARTHRITIS
- Ruptured ligament
- Ruptured joints (dough punchers growths)
- Joint contamination
- Spinal string compression(atlanto hub or upper cervical spine)
- Amyloidosis(rare)s